RISK FACTORS FOR INVASIVE CANDIDIASIS

You may be wondering why you or your loved one developed invasive candidiasis. To help understand this, think about risk factors that: (1) give Candida a portal of entry to invade; (2) weaken the immune system; or (3) promote environmental spread. Most cases of Candida do not spread person-to-person or from contaminated equipment. But this does happen with the species Candida auris and occasionally with other Candida species.

Risk Factors That Can Create a Portal of Entry

Gut surgery or break

GI surgery or other conditions that create a puncture in the gut

Any major surgery

Any major surgery

Central venous catheter

IV lines or ports (e.g., central venous catheters)

Mucositis

Mucositis (inflammation/breaks in the mucous membranes)

injection drug use

Injection-drug use

Hemodialysis

Hemodialysis

LVAD

Prosthetic medical devices (e.g., heart pumps)

burns

Severe burns

Risk Factors for a Weakened Immune System

critical illness

Critical illness

long term icu

Long-term ICU stay

transplant

Transplant

low birth weight

Low birth weight (in a baby)

pancreatitis

Pancreatitis

Neutropenia

Neutropenia (Low white blood cell count)

diabetes

Diabetes mellitus

mechanical ventilation

Mechanical ventilation (use of breathing machines in the ICU)

covid-19

COVID-19

braod spectrum antibiotics

Broad-spectrum antibiotics (change the GI microbiome)

Risk Factors for Environmental Spread (as seen mostly in Candida auris)

Many of the above factors put patients at risk for C. auris. But C. auris is also spread through the environment. Specific risks include:

person to person spread

Person-to-person spread

contaminated medical equipment

Contaminated medical equipment

Even staying in a long-term care hospital or a healthcare facility outside the United States is considered a risk factor for C. auris. See the Q/A section for more details.

Communication Tip:

Ask for a Consultation with an Infectious Diseases (ID) Specialist

Sometimes people develop invasive candidiasis while under the care of a healthcare provider who is not familiar with the disease. The provider may have limited training or experience in managing this serious condition. Therefore, we recommend that patients ask their provider to consult with an ID specialist. Patients with candidiasis who are cared for by an ID specialist have better outcomes than those who don’t have an ID specialist involved. This is true even if the ID specialist is consulted via telemedicine! Consultation with an ID specialist may be required in your hospital, so don’t be afraid to ask for one. And even a non-ID specialist can consult an expert through the CDC’s fungal consult service (404-639-5168 or fungalconsult@cdc.gov ).